What is cytarabine used for?

Cytarabine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Cytarabine is used to treat certain types of leukemia (blood cancers). Cytarabine is also used to treat leukemia associated with meningitis.

Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin’s lymphoma. It is given by injection into a vein, under the skin, or into the cerebrospinal fluid.

how is cytarabine given? Cytarabine may be given as an infusion into the vein (intravenous or IV). Another method it is given is by intrathecal infusion. This method is used when drugs need to reach the cerebrospinal fluid (CSF) the fluid that is surrounding the brain and spinal cord, the drug is infused directly into the spinal fluid.

Besides, what kind of drug is cytarabine?

antimetabolites

Does cytarabine cause hair loss?

It is also FDA approved for use with other drugs to treat acute myeloid leukemia, acute lymphoblastic leukemia and chronic myeloid leukemia. This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.

How often is cytarabine given?

In the induction therapy of acute non-lymphocytic leukemia, the usual cytarabine dose in combination with other anticancer drugs is 100 mg/m2/day by continuous IV infusion (days 1 to 7) or 100 mg/m2 IV every 12 hours (days 1 to 7).

How do you know if the chemo is working?

How do you know if chemotherapy is working? Your oncologist will watch your body’s response during and after chemotherapy. He or she will look for signs that your tumor is shrinking or growing then use tests like physical exams, blood tests, or imaging scans like X-rays.

How much does cytarabine cost?

The cost for cytarabine injectable solution (20 mg/mL) is around $22 for a supply of 25 milliliters, depending on the pharmacy you visit. Injectable Solution. Quantity Per unit Price 25 milliliters $0.90 – $1.43 $22.39 – $35.75 50 milliliters $0.53 – $0.99 $26.30 – $49.40

Does cytarabine cross the blood brain barrier?

Cytarabine crosses the blood brain barrier to a limited extent and is thought to cross the placental barrier. It is not known if cytarabine is distributed into milk. Cerebrospinal fluid levels of cytarabine are low in comparison to plasma levels after single intravenous injection.

What is cytarabine made from?

Cytarabine is isolated from the mushroom Xerocomus nigromaculatus of unknown palatability. Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia.

Where is intrathecal injection given?

Intrathecal administration is a route of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid (CSF) and is useful in spinal anesthesia, chemotherapy, or pain management applications.

Does cytarabine cause fever?

The Cytarabine (Ara-C) Syndrome: A cytarabine syndrome has been described by Castleberry. It is characterized by fever, myalgia, bone pain, occasionally chest pain, maculopapular rash, conjunctivitis, and malaise. It usually occurs 6 to 12 hours following drug administration.

How does cytarabine prevent replication?

Cytarabine is metabolized to an active drug that inhibits DNA synthesis. Cytarabine is an anti-metabolite synthetic nucleoside analogue. Cytarabine A inhibits DNA polymerase in mitotically active cells and produces topoisomerase dysfunction and prevents DNA repair.

How does Cytoxan work?

It is a chemotherapy drug that works by slowing or stopping cell growth. Cyclophosphamide also works by decreasing your immune system’s response to various diseases. It is used to treat a certain type of kidney disease in children after other treatments have not worked.

When did rituximab become available?

November 26, 1997

Who makes cytarabine?

Pfizer

Can cytarabine be given Intrathecally?

Cytarabine Injection is not active orally. Cytarabine Injection may be given by intravenous infusion or injection, subcutaneously, or intrathecally (preservative free preparation only).

What are the side effects of etoposide?

Nausea, vomiting, diarrhea, dizziness, tiredness, weakness, changes in taste, loss of appetite, and pain/redness at the injection site may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.