What is cytarabine syndrome?

Cytarabine syndrome is a rare clinical condition characterized by fever, malaise, myalgia, arthralgia, and/or rash that occurs after receipt of cytarabine. Our patient developed fever, malaise, and diffuse body pain shortly following cytarabine initiation despite receiving prophylactic dexamethasone.

Cytarabine may affect your skin. Cytarabine can cause a rash, which may be itchy. It may also cause your skin to become red or blistered. Always tell your doctor or nurse about any skin changes.

Additionally, how long do cytarabine side effects last? Dizziness, headache, excessive sleepiness, confusion, loss of balance may occur in up to 10% of patients receiving high dose therapy. Onset is usually 5 days after treatment and may last up to 1 week. More often these toxicities are mild and reversible. (see central neurotoxicity).

Also know, is cytarabine a chemo drug?

Cytarabine. Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin’s lymphoma. Cytarabine is in the antimetabolite and nucleoside analog families of medication.

What is cytarabine used for?

Cytarabine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Cytarabine is used to treat certain types of leukemia (blood cancers). Cytarabine is also used to treat leukemia associated with meningitis.

Does cytarabine cause hair loss?

It is also FDA approved for use with other drugs to treat acute myeloid leukemia, acute lymphoblastic leukemia and chronic myeloid leukemia. This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.

What class of drug is cytarabine?

Cytarabine is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body.

How often is cytarabine given?

In the induction therapy of acute non-lymphocytic leukemia, the usual cytarabine dose in combination with other anticancer drugs is 100 mg/m2/day by continuous IV infusion (days 1 to 7) or 100 mg/m2 IV every 12 hours (days 1 to 7).

How much does cytarabine cost?

The cost for cytarabine injectable solution (20 mg/mL) is around $22 for a supply of 25 milliliters, depending on the pharmacy you visit. Injectable Solution. Quantity Per unit Price 25 milliliters $0.90 – $1.43 $22.39 – $35.75 50 milliliters $0.53 – $0.99 $26.30 – $49.40

What is cytarabine made from?

Cytarabine is isolated from the mushroom Xerocomus nigromaculatus of unknown palatability. Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia.

Does cytarabine cause infertility?

Drugs which may cause infertility in men and women include: Alkylating agents- such as busulfan, cisplatin, cyclophosphamide, ifosfamide and melphalan. Other categories of chemotherapy drugs, include Cytarabine, 5-flurouracil, methotrexate, vincristine, vinblastine, bleomycin, doxorubicin, and daunorubicin.

How does Cytoxan work?

It is a chemotherapy drug that works by slowing or stopping cell growth. Cyclophosphamide also works by decreasing your immune system’s response to various diseases. It is used to treat a certain type of kidney disease in children after other treatments have not worked.

Does cytarabine cause fever?

The Cytarabine (Ara-C) Syndrome: A cytarabine syndrome has been described by Castleberry. It is characterized by fever, myalgia, bone pain, occasionally chest pain, maculopapular rash, conjunctivitis, and malaise. It usually occurs 6 to 12 hours following drug administration.

When did rituximab become available?

November 26, 1997

How is cytarabine given?

Cytarabine. Cytarabine is usually given into a vein, an injection under the skin (subcutaneous injection) or by injection into the spinal fluid (intrathecal injection). You usually have it as an outpatient or during a hospital stay. Your cancer doctor or nurse will tell you how often you will have it.

How does cytarabine prevent replication?

Cytarabine is metabolized to an active drug that inhibits DNA synthesis. Cytarabine is an anti-metabolite synthetic nucleoside analogue. Cytarabine A inhibits DNA polymerase in mitotically active cells and produces topoisomerase dysfunction and prevents DNA repair.

Is cytarabine cell cycle specific?

Cytarabine belongs to the category of chemotherapy called antimetabolites. Antimetabolites are very similar to normal substances within the cell. When the cells incorporate these substances into the cellular metabolism, they are unable to divide. Antimetabolites are cell-cycle specific.

Where does asparaginase come from?

asparaginase made from a type of bacteria called Escherichia coli (also known by its brand Spectrila) asparaginase made from the Erwinia chrysanthemia bacteria (Erwinase)