What class of drug is cytarabine?

Cytarabine is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body.

Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin’s lymphoma. It is given by injection into a vein, under the skin, or into the cerebrospinal fluid.

Likewise, what is cytarabine used for? Cytarabine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Cytarabine is used to treat certain types of leukemia (blood cancers). Cytarabine is also used to treat leukemia associated with meningitis.

Keeping this in view, is cytarabine an antimetabolite?

Cytarabine is the generic name for the trade name drug Cytosar-U®. Drug type: Cytarabine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “antimetabolite.” (For more detail, see “How cytarabine works” section below).

Is cytarabine cell cycle specific?

Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle to stop normal cell development and division. Cytarabine is metabolized intracellularly into its active triphosphate form (cytosine arabinoside triphosphate).

How long does cytarabine stay in your system?

This can put you at risk for infection, anemia and/or bleeding. Nadir: White blood cells: 7-10 days, platelets: 12-15 days.

Does cytarabine cause hair loss?

It is also FDA approved for use with other drugs to treat acute myeloid leukemia, acute lymphoblastic leukemia and chronic myeloid leukemia. This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.

How do you know if the chemo is working?

How do you know if chemotherapy is working? Your oncologist will watch your body’s response during and after chemotherapy. He or she will look for signs that your tumor is shrinking or growing then use tests like physical exams, blood tests, or imaging scans like X-rays.

How much does cytarabine cost?

The cost for cytarabine injectable solution (20 mg/mL) is around $22 for a supply of 25 milliliters, depending on the pharmacy you visit. Injectable Solution. Quantity Per unit Price 25 milliliters $0.90 – $1.43 $22.39 – $35.75 50 milliliters $0.53 – $0.99 $26.30 – $49.40

How often is cytarabine given?

In the induction therapy of acute non-lymphocytic leukemia, the usual cytarabine dose in combination with other anticancer drugs is 100 mg/m2/day by continuous IV infusion (days 1 to 7) or 100 mg/m2 IV every 12 hours (days 1 to 7).

Does cytarabine cross the blood brain barrier?

Cytarabine crosses the blood brain barrier to a limited extent and is thought to cross the placental barrier. It is not known if cytarabine is distributed into milk. Cerebrospinal fluid levels of cytarabine are low in comparison to plasma levels after single intravenous injection.

Where is intrathecal injection given?

Intrathecal administration is a route of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid (CSF) and is useful in spinal anesthesia, chemotherapy, or pain management applications.

Is cytarabine a purine analog?

Cytosine arabinoside (cytarabine, ARA-C) Cytarabine is a pyrimidine analog that inhibits DNA polymerase and is used primarily in hematologic cancers.

How does cytarabine prevent replication?

Cytarabine is metabolized to an active drug that inhibits DNA synthesis. Cytarabine is an anti-metabolite synthetic nucleoside analogue. Cytarabine A inhibits DNA polymerase in mitotically active cells and produces topoisomerase dysfunction and prevents DNA repair.

Does cytarabine cause fever?

Fever may occur when cytarabine is given and within 24 hours afterward. Eye drops may ease conjunctivitis and are given with high doses of cytarabine. Children have more problems with vomiting after intrathecal cytarabine than after intrathecal methotrexate.

How do antimetabolites work in the treatment of cancer?

Sulfanilamide drugs are not like the antibiotics used to treat infections. Instead, they work by changing the DNA inside cancer cells to keep them from growing and multiplying.

Are Antimetabolites Cytotoxic?

Antimetabolites. Antimetabolites disrupt nucleic acid synthesis by interfering with production of a major nucleotide metabolite or by substituting for the natural metabolite. Like most cytotoxic anticancer agents, antimetabolites are toxic to normal cells, especially those in the bone marrow and gastrointestinal tract.

What are the most significant side effects of antimetabolites?

Common side effects of these medicines include: Loss of appetite, nausea, or vomiting. Skin rash, which may itch. Diarrhea or constipation. Sores in the mouth or throat. Hair loss. This is reversible, and hair will grow back when treatment ends. Changes in the way foods taste. Weakness or fatigue.